PharmaGuide

(Application contains data on CEPHALOSPORINS only by default. Complete Data is available through yearly subscriptions. Users having complementary Scratch cards can use app with complete data for One Month)

Instant and Predictive Search by:

Brand

Generic Name (e.g. Cefoperazone)

Contents (e.g. Cefoperazone and Sulbactam)

Therapeutic Category (e.g. Cephalosporins)

Interaction Checker:

Interaction Checker feature lets you quickly identify any interaction(s) among prescribed drugs.

You can select GENERICS as well as BRANDS in your country to check interaction.

Risk Factors

Information provided under Risk Factors include Contraindications, Precautions and Risks in Pregnancy and Lactation for the relevant product.

Pregnancy: Risk cannot be ruled out.

Lactation: Contraindicated.

Contraindications: Severe respiratory depression, severe obstructive lung conditions.

Precautions: COPD, raised intracranial pressure, impaired consciousness, head injury, bradyarrhythmia, renal or hepatic impairment. Monitor for signs of respiratory depression. Brain tumour. Risk of tolerance and dependence. Elderly or debilitated patients.

Dosage (Alongwith Indications)

Fast, Quick & Easy Access to Accurate Dosage in Specific Indications

The usual dosage are: Adults: Usually 1 gm daily by deep IM., slow IV inj over at least 2-4 min, or IV infusion. Severe infections, 2-4 gm as a single dose every 24 hrs. Children: Usually 20-50 mg/kg once daily by IM inj., slow IV inj over at least 2-4 min, or IV infusion. Severe infections, up to maximum 80 mg/kg daily. Doses over 50 mg/kg to be given by slow IV infusion over at least 30 minutes. Neonates: IM/IV: Postnatal age ≤ 7 days or > 7 days (body wt ≤ 2 Kg): 50 mg/kg/day given every 24 hrs. Postnatal age > 7 days, body wt > 2 Kg: 50-75 mg/kg/day given every 24 hrs.

Administration

How to prepare and administer e.g. an Injectable

The drug may be administered by IV intermittent infusion over 10-30 min; final concentration for IV administration should not exceed 40 mg/mL. The drug has also been administered by direct IV push over 2-4 min. Inject deep IM into large muscle mass.

IM Injection: 250 mg/500 mg/1000 mg VIAL: To make concentration of 250 mg/mL add Water for Injection 0.9 mL in 250 mg vial; 1.8 mL in 500 mg vial; 3.6 mL in 1000 mg vial.

IV: 250 mg/500 mg/1000 mg VIAL: To make concentration of 100 mg/mL add Water for Injection 2.4 mL in 250 mg vial; 4.8 mL in 500 mg vial; 9.6 mL in 1000 mg vial.

Compatibility: Stable in D5W, D10W, NS, Sodium bicarbonate 5%, bacteriostatic water, SWFI.

Stability: For IV infusion in NS or D5W, solution is stable for 3 days at room temperature or 10 days when refrigerated.

Interactions

Amikacin, Aminoglycosides, Anticoagulants, Gentamicin, Kanamycin, Neomycin, Netilmicin, Streptomycin, Tobramycin, Warfarin.

Adverse Effects

GI upset, skin reactions, blood dyscrasias. Rarely pseudomembranous colitis, raised liver enzymes, glycosuria, oliguria, haematuria, bronchospasm, phlebitis at inj site, urinary and biliary precipitates, pancreatitis.

Alternate Products

Quickly find Alternate Products - Just Click the Appropriate Button

（只应用在默认情况下包含的数据头孢菌素，完整的数据可以通过每年的订阅。具有互补刮刮卡用户可以使用的应用程序具有完整数据一个月）

通过即时与预测搜索：

牌

通用名称（如头孢哌酮）

内容（如头孢哌酮舒巴坦）

治疗类别（如头孢菌素类）

药物相互作用查询：

药物相互作用查询功能可让您快速识别处方药中的任何互动（补）。

您可以在您的国家选择仿制药以及品牌互动检查。

风险因素

在风险因素提供的信息包括禁忌症，注意事项和风险在怀孕和哺乳期的相关产品。

怀孕：风险不能排除。

哺乳期：禁忌。

禁忌症：严重的呼吸抑制，严重的阻塞性肺病的条件。

注意事项：慢性阻塞性肺病，颅内压增高，意识障碍，颅脑损伤，缓慢性心律失常，肾或肝损害。监视呼吸抑制的迹象。脑瘤。耐受性和依赖性的风险。老年人或体弱者。

【用法用量】（非常久远标志）

快速，快速和中具体表现为剂量准确轻松访问

常用剂量为：成人：通常1克，每天深IM，缓慢静脉注射在至少2-4分钟，或静脉注射。严重的感染，2-4克作为单次剂量每24小时。孩子：通常20-50毫克/千克每日1次肌肉注射，静脉缓慢注射在至少2-4分钟，或静脉注射。每天的严重感染，到最大80毫克/公斤。剂量超过50毫克/公斤，以缓慢IV输注超过至少30分钟给予。新生儿：IM / IV：产后年龄≤7天或> 7天（身体重量≤2公斤）：50毫克/公斤/天给予每24小时。产后年龄> 7天，身体重量> 2的。KG：每24小时给予50-75毫克/公斤/天。

行政

如何准备和管理如可注射

该药物可通过静脉输注间断过10-30分钟进行管理;对于IV施用最终浓度应不超过40毫克/毫升。该药物也已通过直接静脉推过2-4分钟服用。注入深IM到大肌肉块。

肌注：250毫克/ 500毫克/ 1000毫克VIAL：使250毫克/ mL浓度添加注射用水0.9毫升250毫克小瓶; 1.8毫升500毫克小瓶; 3.6毫升1000毫克小瓶。

四：250毫克/ 500毫克/ 1000毫克VIAL：为了使100毫克/ mL浓度在250毫克小瓶加注射用水2.4毫升; 4.8毫升500毫克小瓶; 9.6毫升1000毫克小瓶。

兼容性：稳定在D5W，D10W，NS，碳酸氢钠5％，抑菌水，SWFI。

稳定性：对于IV输注在生理盐水或D5W，冷藏时溶液是在室温下3天或10天稳定。

互动

丁胺卡那霉素，氨基糖苷类，抗凝血药，庆大霉素，卡那霉素，新霉素，奈替米星，链霉素，妥布霉素，华法林。

不利影响

胃肠不适，皮肤反应，血液恶液质。很少伪膜性肠炎，肝酶升高，尿糖，少尿，血尿，支气管痉挛，静脉炎在注射部位，尿路和胆道沉淀，胰腺炎。

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